Steven H Bass

Title: **Innovator Spotlight: Steven H. Bass**

Introduction

Steven H. Bass is a prominent inventor based in Redwood City, California. He has made significant contributions to the field of biotechnology, particularly in the development of novel proteins with altered binding properties. With an impressive portfolio of 5 patents, Bass continues to push the boundaries of innovation in protein engineering.

Latest Patents

Among his latest contributions, Bass has developed groundbreaking patents that focus on enrichment methods for variant proteins and monovalent phage display.

The first patent, titled "Enrichment method for variant proteins with altered binding properties," provides a method for selecting novel proteins such as growth hormone and antibody fragment variants. This innovative process involves fusing a gene encoding a protein of interest to the carboxy-terminal domain of the gene III coat protein of the filamentous phage M13. By mutating the gene fusion, a library of structurally related fusion proteins is formed. These proteins are expressed in low quantity on the surface of a phagemid particle, allowing for biological selection and screening to identify novel ligands that may serve as drug candidates.

His second patent, "Monovalent phage display," echoes the methodologies outlined in his first patent, once again focusing on the selection of proteins with altered binding properties. The insights from these patents have significant implications for drug development and therapeutic advancements.

Career Highlights

Steven H. Bass currently works at Genentech, Inc., a leading biotechnology company known for its groundbreaking work in developing medicines. His focus on protein engineering aligns with Genentech's mission to transform the lives of patients with serious diseases through innovative medicines.

Collaborations

Throughout his career, Bass has collaborated with esteemed colleagues such as Ronald Greene and Henry Bernard Lowman. These partnerships have further enhanced his ability to innovate and contribute to the field of biotechnology.

Conclusion

Steven H. Bass exemplifies the spirit of innovation in the biotechnology sector. His dedication to advancing the understanding of protein engineering through his patents underscores the vital role of inventors in developing new therapeutic solutions. As the field progresses, Bass’s work will undoubtedly continue to have a lasting impact on medical science and patient care.