Stephen M Fuchs

Title: Innovations of Stephen M. Fuchs

Introduction

Stephen M. Fuchs is an accomplished inventor based in Carrboro, NC (US). He holds a total of four patents, showcasing his contributions to the field of molecular delivery and fluorescent proteins. His work has significant implications in biological applications and cellular research.

Latest Patents

One of his latest patents is for a modified multilayered film that provides a composition for delivering a molecule into a cell. This composition includes a protein transduction domain conjugated to the molecule, which is incorporated into a multilayered film. The protein transduction domain is preferably a cationic protein transduction domain, with nonaarginine being a more specific example. The multilayered film dissolves or erodes in physiological media, allowing the molecule to be delivered into the cell effectively. Another notable patent involves cell-permeable fluorescent proteins. This invention relates to methods and compositions for designing novel fluorescent proteins, particularly green fluorescent proteins (GFP). The engineered GFPs are modified by substituting negatively charged amino acids with positively charged ones on the exterior of the protein, making it cell permeable. This innovation eliminates the need for transfections, enabling the use of these novel proteins in various biological applications.

Career Highlights

Throughout his career, Stephen has worked with reputable organizations, including the Wisconsin Alumni Research Foundation and Mahidol University. His work has contributed to advancements in molecular biology and protein engineering.

Collaborations

Stephen has collaborated with notable individuals in his field, including Ronald Thaddeus Raines and Parit Plainkum. These collaborations have further enriched his research and innovations.

Conclusion

Stephen M. Fuchs is a prominent inventor whose work in molecular delivery and fluorescent proteins has made a significant impact in the scientific community. His innovative patents continue to influence various biological applications and research methodologies.