The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2014
Filed:
Jan. 22, 2008
David M. Lynn, Middleton, WI (US);
Ronald T. Raines, Madison, WI (US);
Christopher M. Jewell, Madison, WI (US);
Stephen M. Fuchs, Carrboro, NC (US);
Ryan M. Flessner, Middleton, WI (US);
David M. Lynn, Middleton, WI (US);
Ronald T. Raines, Madison, WI (US);
Christopher M. Jewell, Madison, WI (US);
Stephen M. Fuchs, Carrboro, NC (US);
Ryan M. Flessner, Middleton, WI (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
A composition for delivery of a molecule into a cell is provided. The composition includes a protein transduction domain that is conjugated to the molecule which is incorporated into a multilayered film. Preferably, the protein transduction domain is a cationic protein transduction domain. More preferably, the cationic protein transduction domain is nonaarginine, and the multilayered film includes polyelectrolyte multilayers. When the composition is presented to a cell, the multilayered film dissolves or erodes in physiological media, and the molecule is delivered into the cell.