Stephen Little

Title: The Innovative Contributions of Stephen Little

Introduction

Stephen Little is a notable inventor based in Northwich, GB. He has made significant contributions to the field of nucleic acid detection, holding a total of 4 patents. His work has advanced methodologies that are crucial for genetic research and diagnostics.

Latest Patents

Among his latest patents is a method for detecting allelic imbalance. This innovative technique involves providing multiple copies of a target nucleic acid region, which includes a marker of heterozygosity. The process separates these copies into individual strands, allowing them to reanneal under specific conditions. This method amplifies any differences in the initial ratio of allelic variants, enabling the detection of allelic imbalance by analyzing the allele ratio.

Another significant patent by Stephen Little focuses on methods for detecting target nucleic acid sequences. This method involves contacting template nucleic acid from a sample with a signaling system and a tailed nucleic acid primer. The primer hybridizes to a complementary sequence in the template nucleic acid, leading to a detectable change in the signaling system that indicates the presence or absence of the target nucleic acid.

Career Highlights

Stephen Little has worked with prominent companies in the biotechnology sector, including Zeneca Limited and Syngenta Corporation. His experience in these organizations has contributed to his expertise in nucleic acid technologies and innovations.

Collaborations

Throughout his career, Stephen has collaborated with notable individuals such as David Mark Whitcombe and Jannine Brownie. These partnerships have further enriched his work and expanded the impact of his inventions.

Conclusion

Stephen Little's contributions to the field of nucleic acid detection are invaluable. His innovative patents and career experiences highlight his role as a leading inventor in biotechnology.