Company Filing History:
Years Active: 1994-2000
Title: Innovations of Stephen L Warren
Introduction
Stephen L Warren is a notable inventor based in Orange, CT (US). He has made significant contributions to the field of molecular biology, particularly in the development of innovative methods for macromolecular delivery and genetic therapy technologies. With a total of 3 patents, his work has the potential to impact various areas of research and medicine.
Latest Patents
Warren's latest patents include groundbreaking work on RNA polymerase II peptides and methods of use. This macromolecular delivery method utilizes a series of peptides with unique nuclear targeting properties, derived from the COOH terminal domain (CTD) of the largest subunit of RNA polymerase II. The peptides include heptapeptide units that are similar or identical to a specific consensus sequence. When expressed in vivo, these CTD peptides are phosphorylated and accumulate in discrete compartments within the nucleus. This accumulation allows for the concentration of indicator molecules in areas where pre-mRNA molecules are synthesized and spliced. The versatility of the CTD peptides can be manipulated to achieve different intranuclear partitioning properties, making them functional across various organisms, including yeast, nematodes, insects, plants, and vertebrates.
Another significant patent involves a macromolecule delivery method and composition that utilizes antibodies to the large subunit of DNA-dependent RNA polymerase II. This invention serves as a research tool and diagnostic method for proliferative diseases such as cancer. The anti-Pol II LS antibodies are highly specific for phosphorylated Pol II LS and bind in a phosphorylation-dependent manner, allowing for targeted delivery of therapeutic molecules to predetermined sites within the nucleus of a cell.
Career Highlights
Stephen L Warren is affiliated with Yale University, where he continues to advance his research in molecular biology. His work has garnered attention for its innovative approach to genetic therapy and molecular delivery systems.
Collaborations
Warren has collaborated with notable colleagues, including Leonard Bell and Joseph A Madri, contributing to the advancement of research in his field.
Conclusion
Stephen L Warren's contributions to molecular biology through his innovative patents highlight the potential for advancements in genetic therapy and targeted delivery methods. His work continues to inspire future research and applications in the field.