Stephen L Ledis

Title: The Innovations of Stephen L. Ledis

Introduction

Stephen L. Ledis is a notable inventor based in Pembroke Pines, FL (US). He has made significant contributions to the field of biochemistry, particularly through his innovative work with aminodextran compositions. His research has implications for various applications, including cell labeling and reagent development.

Latest Patents

Stephen L. Ledis holds a patent for "Aminodextran compositions and conjugates and method of making and using them." This patent describes a composition containing polydisperse aminodextran polymer molecules that are soluble in an aqueous solution at a concentration of 10 mg/ml. The molecules have a narrow size distribution characterized by an average molecule mean hydrodynamic diameter of greater than 115 nm, a polydispersity index of between 0.10 and 0.47, an average molecular weight (MW) greater than 3 million daltons, and an amine content of greater than 50 amines per molecule. Additionally, similar soluble compositions contain polymer molecules with an average MW of greater than 7 million daltons. These compositions are particularly useful in forming reagents by conjugation with proteins for labeling cells. The methods of making these compositions and reagents involve fractionation on column chromatography.

Career Highlights

Stephen L. Ledis is currently associated with Beckman Coulter, Inc., where he continues to advance his research and development efforts. His work has been instrumental in enhancing the understanding and application of aminodextran polymers in scientific research.

Collaborations

Stephen has collaborated with notable colleagues such as Olavi Siiman and Cynthia G. Healy, contributing to a dynamic research environment that fosters innovation and discovery.

Conclusion

Stephen L. Ledis exemplifies the spirit of innovation through his contributions to biochemistry and polymer science. His patent on aminodextran compositions highlights the potential for advancements in cell labeling and reagent development.