This inventor holds 1 USPTO granted patent. Top assignee: University of Illinois. Active years: 2009.
Company Filing History:
Years Active: 2009
Title: Innovations of Stephen James Grimme
Introduction
Stephen James Grimme is an accomplished inventor based in Urbana, IL (US). He is known for his significant contributions to the field of membrane scaffold proteins. His work has implications for pharmaceutical and biological research, enhancing the understanding of protein structures and functions.
Latest Patents
Stephen Grimme holds a patent for "Membrane scaffold proteins." This invention involves the assembly of membrane scaffold proteins (MSP) with hydrophobic or partially hydrophobic proteins to create soluble nanoscale particles. These particles maintain native structure and function, offering improvements over traditional liposomes and detergent micelles in terms of stability and preservation of biological activity. The MSPs form nanoscopic phospholipid bilayer disks in the presence of phospholipids, stabilizing the particle at the perimeter of the bilayer domain. This innovative structure allows for the manipulation of incorporated proteins in various applications, including surface-sensitive techniques such as scanning probe microscopy and surface plasmon resonance. The robust nanoscale particles facilitate advancements in pharmaceutical and biological research, structure/function correlations, structure determinations, bioseparations, and drug discovery.
Career Highlights
Stephen Grimme is affiliated with the University of Illinois, where he continues to contribute to research and innovation in his field. His work has garnered attention for its potential to revolutionize how proteins are studied and utilized in various scientific applications.
Collaborations
Stephen Grimme has collaborated with notable colleagues, including Stephen G. Sligar and Timothy H. Bayburt. These partnerships have further enriched his research and expanded the impact of his innovations.
Conclusion
Stephen James Grimme's work on membrane scaffold proteins represents a significant advancement in the field of protein research. His innovative approach has the potential to enhance various applications in pharmaceutical and biological sciences.