Stephen H Howell

Title: Innovations of Stephen H Howell

Introduction

Stephen H Howell is a notable inventor based in Del Mar, California. He has made significant contributions to the field of bioluminescence through his innovative patents. With a total of four patents to his name, Howell's work has advanced the understanding and application of luciferase proteins.

Latest Patents

One of Howell's latest patents is titled "Recombinantly produced Coleoptera luciferase and fusion proteins thereof." This patent discloses a method for producing a protein that expresses bioluminescence activity. The method involves combining two polydeoxyribonucleotides, one encoding a polypeptide that catalyzes the oxidation of insect luciferin to yield light, and the other facilitating DNA transcription. The insect luciferin is derived from bioluminescent insects, preferably from the Diptera and Coleoptera families, such as fireflies and beetles. Additionally, Howell's patent describes a method for quantitatively assaying a fluid for the presence of an unknown quantity of antigen using hybrid proteins bonded to antibodies directed against the antigen.

Another significant patent is focused on "DNA sequences encoding coleoptera luciferase activity." This patent includes DNA compositions and methods for constructing and using DNA sequences that encode luciferase activity or hybrid molecules exhibiting luciferase activity alongside a second biological activity. These innovations are particularly useful in performing biological assays.

Career Highlights

Stephen H Howell is affiliated with the University of California, where he continues to contribute to research and innovation in bioluminescence. His work has not only advanced scientific understanding but has also opened new avenues for practical applications in various fields.

Collaborations

Howell has collaborated with notable individuals in his field, including Marlene DeLuca McElroy, who is now deceased, and Donald R Helinski. These collaborations have enriched his research and contributed to the success of his innovative projects.

Conclusion

Stephen H Howell's contributions to the field of bioluminescence through his patents demonstrate his innovative spirit and dedication to scientific advancement. His work continues to inspire future research and applications in biological sciences.