Company Filing History:
Years Active: 1994
Title: The Innovations of Stephen E Zale
Introduction
Stephen E Zale is an accomplished inventor based in Uxbridge, MA (US). He holds 2 patents that showcase his expertise in the field of affinity separations and protein purification. His work has significant implications for the recovery of biologically active proteins from complex mixtures.
Latest Patents
Zale's latest patents include "High-capacity affinity supports and methods for the preparation and use." This invention features an affinity support designed to enhance the binding capacity for target compounds. The support incorporates an immobilized modified ligand with increased molecular weight, achieved through the use of condensation reagents or crosslinkers prior to immobilization. This innovation is particularly useful in affinity separations of proteins and other biomolecules from biologically-derived fluids.
Another notable patent is "Method and apparatus for eluting proteins in affinity membrane process." This invention outlines methods and apparatus for conducting affinity separations of proteins under optimized conditions for recovering biologically active protein. The method employs a membrane-bound ligand to capture and separate a ligate from a fluid mixture, subsequently releasing the ligate in a purified form. This approach enhances the yield of active ligate recovered during the process, making it especially relevant for protein recovery and purification.
Career Highlights
Throughout his career, Stephen E Zale has worked with notable companies such as Sepracor, Inc. and Randal A. Goffe. His contributions to the field of biotechnology and protein purification have been recognized and valued in various professional settings.
Collaborations
Zale has collaborated with esteemed colleagues, including Clark K Colton and Randal A. Goffe. These partnerships have further enriched his work and expanded the impact of his inventions.
Conclusion
Stephen E Zale's innovative contributions to affinity separations and protein purification demonstrate his significant role in advancing biotechnology. His patents reflect a commitment to enhancing the efficiency and effectiveness of protein recovery processes.