Stephen D Lupton

Title: Innovations and Contributions of Stephen D. Lupton

Introduction

Stephen D. Lupton is a prominent inventor based in Seattle, WA, known for his significant contributions to the field of biotechnology. He holds a total of 15 patents, showcasing his innovative spirit and dedication to advancing scientific knowledge. His work primarily focuses on the development of recombinant vectors and selectable fusion genes, which have important applications in immunotherapy and genetic engineering.

Latest Patents

One of Lupton's latest patents is titled "Hybrid genes for expression of stimulatory factors in activated T cells." This invention provides recombinant vectors that enhance the proliferative response of activated lymphocytes, particularly cytotoxic T lymphocytes, by reducing their dependency on T helper cells. The vectors include a region encoding a stimulatory factor polypeptide linked to a heterologous transcriptional control region. This innovation allows for improved immunotherapy applications by enabling activated lymphocytes to respond more effectively to their cognate antigens.

Another notable patent is "Bifunctional selectable fusion genes." This invention introduces selectable fusion genes that combine a dominant positive selectable gene with a negative selectable gene. The resulting bifunctional fusion protein can confer both a dominant positive selectable phenotype and a negative selectable phenotype on a cellular host. This technology is crucial for enhancing the efficiency of gene expression and regulation in various applications, including the development of recombinant expression vectors.

Career Highlights

Throughout his career, Stephen D. Lupton has worked with several notable companies, including Immunex Corporation and Targeted Genetics Corporation. His experience in these organizations has allowed him to collaborate with leading experts in the field and contribute to groundbreaking research and development.

Collaborations

Lupton has collaborated with esteemed colleagues such as Anthony E. Namen and Raymond G. Goodwin. These partnerships have further enriched his work and expanded the impact of his inventions in the biotechnology sector.

Conclusion

Stephen D. Lupton's innovative contributions to biotechnology, particularly in the areas of recombinant vectors and selectable fusion genes, have made a significant impact on the field. His work continues to influence advancements in immunotherapy and genetic engineering, showcasing the importance of innovation in scientific research.