Location History:
- Maplewood, NJ (US) (1978 - 1996)
- Silver Spring, MD (US) (1981 - 2004)
Company Filing History:
9 out of 1,217 
3 out of 3 
1 out of 3,539 
Years Active: 1978-2004
Title: An Insight into the Innovations of Stephen B. Leighton
Introduction
Stephen B. Leighton, an esteemed inventor based in Maplewood, NJ, has made remarkable contributions to the field of molecular profiling through his innovative inventions. With a total of 20 patents to his name, Leighton's work has significantly advanced techniques used in cancer research and diagnosis.
Latest Patents
Among his most recent patents, Leighton has developed groundbreaking technologies such as tumor tissue microarrays for rapid molecular profiling. This array-based technology enables efficient gene copy number and expression profiling across vast numbers of human tumor samples. By utilizing hundreds of cylindrical tissue biopsies from representative tumor regions organized in a single paraffin block, his approach facilitates high-throughput genomic analysis.
For instance, his technology has successfully assessed amplifications of critical gene loci in over 370 ethanol-fixed breast cancer samples, revealing distinct gene amplification patterns that could have important prognostic implications. In addition to this, Leighton has also invented a punch-changing tissue array instrument. This device allows for the creation of biological tissue arrays by automating the process of core extraction from donor blocks, thus enhancing the efficiency of tissue sample preparation.
Career Highlights
Throughout his career, Stephen B. Leighton has been affiliated with prominent organizations, including the United States Department of Health. His dedication to advancing medical research and diagnostics has earned him recognition in various biotechnology and health sectors.
Collaborations
Leighton has collaborated with notable individuals in the field, including James L. Olds and William H. Boyd. These partnerships have fostered innovative research projects, contributing to the enhancement of molecular profiling technologies and improving cancer diagnosis and treatments.
Conclusion
Stephen B. Leighton's inventive spirit and scientific commitment have propelled advancements in cancer research. His patents not only reflect his ingenuity but also signify his vital role in transitioning medical diagnostics toward more efficient, accurate methodologies. As innovations continue to emerge from his work, Leighton remains a key figure in the realm of molecular profiling and cancer research.