Company Filing History:
1 out of 832,961 Years Active: 2008
Title: Innovations by Stephan Guessregen
Introduction
Stephan Guessregen is an accomplished inventor based in Holsworthy, GB. He has made significant contributions to the field of compound database searching through his innovative methods. His work focuses on enhancing the efficiency of identifying compounds with similar biological activities.
Latest Patents
Stephan Guessregen holds a patent for a method titled "Method for searching heterogeneous compound databases using topomeric shape descriptors and pharmacophoric features." This patent describes a process where heterogeneous compound databases can be searched for compounds likely to exhibit the same biological activity as a known query molecule. The method involves fragmenting both the query molecules and database compounds according to established fragmentation rules. These fragments are then aligned in a uniform conformation using a topomeric alignment process. Interaction energy fields, typically steric fields, are generated to capture the shapes of the fragments. By comparing the fields of the query fragments with those of the database compound fragments, a measure of shape similarity is obtained. This method also allows for the search of similarly shaped substructures and cores, with pharmacophoric features defined for the aligned fragments based on user-specified importance.
Career Highlights
Stephan has demonstrated a strong commitment to advancing the field of compound searching. His innovative approach has the potential to significantly impact drug discovery and development processes. With a focus on both shape and feature similarity, his work provides a comprehensive tool for researchers in the pharmaceutical industry.
Collaborations
Stephan has collaborated with notable professionals in his field, including Richard D Cramer and Robert Jilek. These collaborations have likely contributed to the refinement and application of his innovative methods.
Conclusion
Stephan Guessregen's contributions to the field of compound database searching exemplify the importance of innovation in scientific research. His patented method enhances the ability to identify biologically relevant compounds, paving the way for advancements in drug discovery.