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Years Active: 2014
Title: The Innovations of Stephan Bertel
Introduction
Stephan Bertel is a notable inventor based in Kundl, Austria. He has made significant contributions to the field of pharmaceuticals, particularly in the development and processing of complex compounds. With a total of 2 patents, his work has had a meaningful impact on medical science.
Latest Patents
One of his latest patents is titled "Preparation of romidepsin." This invention provides an improved process for preparing romidepsin, which involves producing, purifying, or storing the compound under conditions that prevent the formation of undesired adducts. It has been discovered that purifying romidepsin at an apparent pH lower than approximately 6.0 can prevent the reduction of the disulfide bond of romidepsin, thereby avoiding the formation of dimerized, oligomerized, or polymerized adducts. The invention also includes compositions of monomeric romidepsin that are free of these adducts.
Another significant patent is the "Method for processing microbiologically produced cyclic oligopeptides." This invention relates to a method for processing non-polar, cyclic oligopeptides that are produced microbiologically. The method involves extracting the entire fermentation broth using a liquid extractant that contains ether and is immiscible with water, forming a two-phase system with the fermentation broth. This innovative approach also includes novel solvates of cyclosporin A and methyl-t-butyl ether.
Career Highlights
Stephan Bertel has worked with prominent companies in the pharmaceutical industry, including Celgene Corporation and Sandoz GmbH. His experience in these organizations has contributed to his expertise in the field and has allowed him to develop groundbreaking inventions.
Collaborations
Throughout his career, Bertel has collaborated with notable individuals such as Gregory Lawrence Verdine and Nicholas H. Vrolijk. These partnerships have further enriched his work and have led to advancements in pharmaceutical research.
Conclusion
Stephan Bertel's contributions to the field of pharmaceuticals through his innovative patents and collaborations highlight his importance as an inventor. His work continues to influence the development of medical treatments and compounds.