Company Filing History:
2 out of 2 
1 out of 313 
1 out of 3 Years Active: 1994-2022
Title: Inventor Profile: Stefano Iacobelli
Introduction
Stefano Iacobelli, based in Rome, Italy, is a distinguished inventor with a remarkable contribution to the field of biomedicine. He holds a total of four patents, showcasing his dedication to advancing innovative therapeutic solutions. His latest inventions focus on antibodies targeting specific receptors associated with tumor biology, marking significant strides in cancer research and treatment.
Latest Patents
His notable patents include the development of an Endosialin-binding antibody. This groundbreaking invention involves generating an antibody that specifically recognizes and binds to Endosialin, a cell surface antigen noted for its presence in tumor pericytes and tumor stroma cells. The antibody not only internalizes in Endosialin-expressing cells but also inhibits MAPK activation in PDGF stimulated human pericytes. Furthermore, it blocks angiogenesis induced by LGALS3BP and demonstrates a capability to inhibit tumor growth both independently and in conjunction with a humanized antibody targeting LGALS3BP in human osteosarcoma xenograft models. Additionally, the humanized version of the anti-Endosialin antibody, when conjugated with a duocarmycin derivative, exhibits potent in vitro tumor cell cytotoxicity as well as effective antitumor efficacy in vivo. Another key patent involves an ErbB3 binding antibody, which is a monoclonal antibody that specifically binds to the ErbB3 receptor, promising diverse applications in therapeutic compositions and methodologies.
Career Highlights
Stefano Iacobelli has collaborated with notable organizations, including Mediapharma S.r.l. and the National Research Council of Italy (Consiglio Nazionale Delle Ricerche). His work in these institutions has further solidified his reputation as a leading innovator in the biopharmaceutical sector.
Collaborations
Throughout his career, Iacobelli has worked alongside esteemed colleagues, including Gianluca Sala and Raffaella Muraro. Their collaborative efforts have been instrumental in the further development and improvement of the innovative concepts he has presented through his patent applications.
Conclusion
Stefano Iacobelli exemplifies the spirit of innovation in the biomedicine field. His work on therapeutic antibodies not only contributes to our understanding of cancer biology but also opens new avenues for effective therapies. With his track record of patents and collaborations, Iacobelli continues to be a pivotal figure in the advancement of medical science, inspiring future inventors to explore the frontiers of innovation.