This inventor holds 1 USPTO granted patent. Top assignee: The University of Texas System. Active years: 1993.
Company Filing History:
Years Active: 1993
Title: Innovations of Stanley D. Tucker in Cytotoxin Research
Introduction
Stanley D. Tucker is a notable inventor based in Houston, TX, who has made significant contributions to the field of cytotoxin research. His work focuses on developing compositions that inhibit mitochondrial respiration, which has important implications for cellular health and disease treatment.
Latest Patents
Stanley D. Tucker holds a patent for "Macrophage cytotoxin compositions and methods of preparation." This invention provides a cytotoxin composition that inhibits mitochondrial respiration and causes cytostasis in cells, independent of nitric oxide. The invention comprises a conditioned supernatant derived from a macrophage cell line (EA13.5) that inhibits mitochondrial respiration and causes cytostasis in cells. More particularly, the invention comprises a macrophage cytotoxin obtained from conditioned supernatant collected from cultured EA13.5 cells. This macrophage cytotoxin (1) inhibits mitochondrial respiration, (2) causes cytostasis independent of L-arginine derived nitric oxide, and (3) is a weakly acidic glycoprotein with a pI of about 7.5 to 8.0, as determined by binding to lentil lectin sepharose. The invention also discloses a method for producing an L-arginine-derived nitric oxide-independent macrophage cytotoxin by culturing EA13.5 cells, adding IFN-.gamma. and lipopolysaccharide to trigger secretion of the macrophage cytotoxin into the conditioned supernatant, collecting the conditioned supernatant, and isolating the macrophage cytotoxin from the conditioned supernatant. Furthermore, the invention describes a method for producing a nitric oxide-independent macrophage cytotoxin that inhibits mitochondrial respiration independent of L-arginine from cultured rodent macrophages.
Career Highlights
Stanley D. Tucker is affiliated with The University of Texas System, where he continues to advance research in the field of cytotoxins. His innovative work has led to the development of new methodologies that enhance our understanding of cellular processes and potential therapeutic applications.
Collaborations
Stanley has collaborated with notable colleagues such as Mathoor Sivaramakrishnan and Jim Klostergaard, contributing to a rich environment of research and innovation.
Conclusion
Stanley D. Tucker's contributions to cytotoxin research exemplify the