This inventor holds 6 USPTO granted patents and 3 published patent applications. Top assignee: American Cyanamid Company. Active years: 1993-1998.
Location History:
- Grandview, NY (US) (1993 - 1997)
- Rockland, NY (US) (1997 - 1998)
Company Filing History:
Years Active: 1993-1998
Title: The Innovative Contributions of Sotirios K Karathanasis
Introduction
Sotirios K Karathanasis is a notable inventor based in Rockland, NY (US). He has made significant contributions to the field of biochemistry and molecular biology, holding a total of 6 patents. His work primarily focuses on the development of methods for screening compounds that interact with retinoid X receptors.
Latest Patents
One of his latest patents is a mechanism-based screen for retinoid X receptor agonists and antagonists. This method utilizes a retinoid X receptor expressed by a yeast expression system to identify compounds with agonist or antagonist activity. The process involves providing a yeast strain that expresses the retinoic acid receptor and activates a reporter plasmid containing the apolipoprotein AI gene site A or its mutated variants. The compound is then incubated in suitable media with a colorless chromogenic substrate, and the media is examined for color development. This innovative approach also describes mutated variants of the apolipoprotein AI gene site A that respond selectively to the retinoid X receptor or to other receptors.
Career Highlights
Sotirios K Karathanasis has had a distinguished career, working at the American Cyanamid Company. His expertise in the field has led to the development of groundbreaking methods that enhance the understanding of retinoid X receptor interactions.
Collaborations
Throughout his career, he has collaborated with notable colleagues such as Paul Wai Mak and Andrew S Katocs, Jr. These partnerships have contributed to the advancement of research in his area of expertise.
Conclusion
Sotirios K Karathanasis is a prominent inventor whose work has significantly impacted the field of biochemistry. His innovative patents and collaborations continue to influence research and development in the study of retinoid X receptors.