Slobodan Barbaric

Title: The Innovations of Slobodan Barbaric

Introduction

Slobodan Barbaric is a notable inventor based in Zagreb, YU. He has made significant contributions to the field of glycoprotein stabilization, showcasing his expertise through his innovative patent.

Latest Patents

Barbaric holds a patent for the "Stabilization of glycoproteins," which details a process for preparing stabilized glycoproteins without introducing foreign molecules. This process involves the periodate oxidation of susceptible monosaccharides that are covalently attached to the protein part of the molecule. After eliminating the remaining periodate, the oxidized glycoprotein is incubated in a buffer under favorable conditions. This allows for a reaction between the aldehyde groups generated in the sugar part and the amino acid residues from the protein part. The oxidized carbohydrate chains serve as a polyaldehyde crosslinker, leading to the production of intramolecularly and intermolecularly linked derivatives. The amount and size of these derivatives can be controlled by the degree of oxidation and protein concentration. Under optimal conditions, the thermal stability of the glycoprotein can be about 10 times better than that of native invertase. Additional stabilization can be achieved through reduction with NaCNBH.sub.3.

Career Highlights

Throughout his career, Slobodan Barbaric has demonstrated a commitment to advancing the field of biochemistry. His innovative approach to glycoprotein stabilization has the potential to impact various applications in biotechnology and pharmaceuticals.

Collaborations

Barbaric has collaborated with Branko Kozulic, further enhancing his research and development efforts in the field.

Conclusion

Slobodan Barbaric's contributions to the stabilization of glycoproteins highlight his innovative spirit and dedication to scientific advancement. His patent reflects a significant step forward in biochemistry, showcasing the potential for improved stability in glycoprotein applications.