Location History:
- Gdansk, PL (2013)
- Gdańsk, PL (2013)
Company Filing History:
Years Active: 2013
Title: The Innovative Contributions of Slawomir Makowiec
Introduction
Slawomir Makowiec, an accomplished inventor based in Gdansk, Poland, has made significant strides in the field of pharmaceutical chemistry. With a total of two patents to his name, his work primarily revolves around the preparation of bisphosphonic acids, compounds that have essential applications in medicinal chemistry.
Latest Patents
Makowiec's recent patents showcase his innovative approach to chemical synthesis. The first patent involves a process for the preparation of [1-hydroxy-2-(1-imidazol-1-yl)-ethylidene]bisphosphonic acid. This invention details a procedure that starts with the reaction of an aqueous solution of 1H-imidazole-1-acetic acid hydrochloride with phosphorus trichloride. The subsequent steps include the removal of excess phosphorus trichloride, addition of water, and hydrolysis of the reaction products. Finally, the product is isolated by filtering the post-reaction mixture and crystallizing out the [1-hydroxy-2-(1-imidazol-1-yl)-ethylidene]bisphosphonic acid monohydrate through the addition of an anti-solvent.
In his second patent, Makowiec presents a process for preparing [1-hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid and its hemipentahydrate monosodium salt. This innovative method involves several steps: the reaction of an aqueous solution of 3-pyridyl acetic acid hydrochloride with phosphorus trichloride, followed by the removal of unreacted phosphorus trichloride. After hydrolysis and crystallization, the final product is obtained through a series of washes and drying.
Career Highlights
As a dedicated researcher, Slawomir Makowiec works at Zaklady Farmaceutyczne Polpharma S.A., a prominent pharmaceutical company known for its commitment to research and innovation. His role in the company underscores his position within the industry and reflects the importance of his contributions to pharmaceutical advancements.
Collaborations
Throughout his career, Makowiec has collaborated with notable coworkers such as Leszek Dembkowski and Robert Rynkiewicz. Together, they have fostered a working environment that encourages innovation and the development of new pharmaceutical processes.
Conclusion
Slawomir Makowiec stands out as an inventor whose contributions have the potential to influence the future of pharmaceutical chemistry significantly. His innovative patents not only exemplify his expertise but also demonstrate the importance of collaboration and perseverance within the research community. Through his work at Zaklady Farmaceutyczne Polpharma S.A., he continues to push the boundaries of innovation, paving the way for future advancements in the field.