The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2013
Filed:
Oct. 17, 2009
Leszek Dembkowski, Pruszcz Gdanski, PL;
Mariusz Krzyzanowski, Skórcz, PL;
Robert Rynkiewicz, Starogard Gdanski, PL;
Roman Szramka, Starogard Gdanski, PL;
Zdzislaw Roznerski, Starogard Gdanski, PL;
Daniel Zyla, Starogard Gdanski, PL;
Janusz Rachon, Gdansk, PL;
Slawomir Makowiec, Gdansk, PL;
Leszek Dembkowski, Pruszcz Gdanski, PL;
Mariusz Krzyzanowski, Skórcz, PL;
Robert Rynkiewicz, Starogard Gdanski, PL;
Roman Szramka, Starogard Gdanski, PL;
Zdzislaw Roznerski, Starogard Gdanski, PL;
Daniel Zyla, Starogard Gdanski, PL;
Janusz Rachon, Gdansk, PL;
Slawomir Makowiec, Gdansk, PL;
Zaklady Farmaceutyczne Polpharma SA, Gdansk, PL;
Abstract
A process for the preparation of [1-hydroxy-2-(1-imidazol-1-yl)-ethylidene]bisphosphonic acid consists of the reaction of aqueous solution of 1H-imidazole-1-acetic acid hydrochloride with phosphorus trichloride followed by removal of the excess of phosphorus trichloride, addition of water and hydrolysis of the reaction products. In order to isolate the product the post-reaction mixture is filtered and the anti-solvent is added to the aqueous filtrate in order to crystallize out [1-hydroxy-2-(1-imidazol-1-yl)-ethylidene]bisphosphonic acid monohydrate.