Location History:
- Manlius, NY (US) (2008)
- Syracuse, NY (US) (2009)
Company Filing History:
Years Active: 2008-2009
Title: Innovations in Protein Production: The Contributions of Sivakesava Sakhamuri
Introduction
Sivakesava Sakhamuri, an accomplished inventor based in Syracuse, NY, has made significant strides in the field of protein production through innovative cell culture processes. With two patents to his name, his work focuses primarily on enhancing the quality and viability of proteins, particularly glycoproteins, using mammalian cell cultures.
Latest Patents
Sivakesava's latest patents detail groundbreaking methods for the production of proteins. The first patent emphasizes mammalian cell culture processes involving temperature shifts to maintain cell viability during the culturing period and improve protein yield. This method includes performing at least two temperature shifts, where the final temperature is lower, ensuring high cell viability and increased protein productivity. Additionally, the delayed addition of polyanionic compounds enhances cell viability and prolongs the growth phase.
His second patent further complements these innovations by addressing product quality enhancement in mammalian cell culture. It outlines the use of D-galactose supplementation in the feed medium to sustain effective sialylation levels of produced proteins. This approach not only supports cell viability but also preserves protein quality, particularly in large-scale culturing processes.
Career Highlights
Sivakesava Sakhamuri is affiliated with Bristol-Myers Squibb Company, where he collaborates with other esteemed professionals in the field. His innovative approaches to protein production have contributed significantly to the advancement of biopharmaceutical manufacturing processes, ensuring higher-quality therapeutic proteins.
Collaborations
Throughout his career, Sivakesava has worked alongside notable colleagues such as Bernhard M. Schilling and Linda Matlock. Their collaborative efforts in research and development have facilitated groundbreaking advancements in cell culture technology and protein production, fostering a dynamic environment for innovation.
Conclusion
Sivakesava Sakhamuri exemplifies the spirit of innovation within the biotechnology industry. His dedicated work on mammalian cell culture processes not only enhances the efficiency of protein production but also improves the quality of therapeutic proteins. As he continues to contribute to advancements in this field, his patents will undoubtedly have a lasting impact on biopharmaceutical development.