Location History:
- Marlboro, MA (US) (1997 - 2000)
- Hudson, MA (US) (1999 - 2002)
- Marlborough, MA (US) (2002)
Company Filing History:
13 out of 789 
1 out of 903 
Years Active: 1997-2002
Title: Simon J Eastman: Innovator in Gene Therapy
Introduction
Simon J Eastman is a prominent inventor based in Marlboro, MA (US). He has made significant contributions to the field of gene therapy, holding a total of 13 patents. His work focuses on improving the efficiency of gene delivery systems, particularly in polarized epithelial cells.
Latest Patents
One of Eastman's latest patents addresses the challenges of transgene expression in polarized cells. The well-differentiated airway epithelium is a primary target for gene therapy in the treatment of cystic fibrosis (CF). Recent studies have indicated that traditional gene delivery vehicles, such as cationic lipid:DNA complexes, often struggle to effectively bind and internalize into these specialized cells. Eastman's invention proposes a method to enhance gene therapy by utilizing compounds that disrupt tight junctions. This approach improves the transfection of biologically active molecules through cationic amphiphile:biologically active molecule complexes or other lipid, viral, or nonviral vectors by treating the cells with absorption enhancers or tight junction disrupting compounds.
Career Highlights
Throughout his career, Simon J Eastman has worked with notable organizations, including Genzyme Corporation and the University of Iowa Research Foundation. His innovative research has positioned him as a key figure in the advancement of gene therapy technologies.
Collaborations
Eastman has collaborated with esteemed colleagues such as Seng H Cheng and Ronald K Scheule, contributing to the development of groundbreaking solutions in his field.
Conclusion
Simon J Eastman's work exemplifies the intersection of innovation and practical application in gene therapy. His contributions continue to pave the way for advancements in the treatment of genetic disorders.