The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 1999
Filed:
Jul. 15, 1996
John Marshall, Milford, MA (US);
David J Harris, Lexington, MA (US);
Edward R Lee, Quincy, MA (US);
Craig S Siegel, Woburn, MA (US);
Simon J Eastman, Marlboro, MA (US);
Chau-Dung Chang, Lexington, MA (US);
Ronald K Scheule, Hopkinton, MA (US);
Seng H Cheng, Wellesley, MA (US);
Genzyme Corporation, Cambridge, MA (US);
Abstract
Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. By this invention, such cationic amphiphile is used in a state in which it is capable of accepting additional protons, i.e., it is not fully protonated. For purposes of this invention, cationic amphiphiles may be considered to encompass four general categories: (A) T-shaped/steroid-based amphiphiles; (B) T-shaped/non steroid-based amphiphiles; (C) non T-shaped/steroid based amphiphiles and (D) non T-shaped/non steroid-based amphiphiles.