Company Filing History:
Years Active: 2000
Title: The Innovative Contributions of Simon J Davis in Glycoprotein Engineering
Introduction: Simon J Davis, based in Oxford, GB, has made significant strides in the field of biotechnology through his innovative methods for carbohydrate engineering of glycoproteins. His work is particularly relevant for enhancing the structural and functional analysis of glycoproteins, which play crucial roles in various biological processes.
Latest Patents: Simon J Davis holds a patent titled "Method for carbohydrate engineering of glycoproteins." This patent describes a novel method for modifying the carbohydrate moiety on glycoproteins, which aids in structural and functional analyses through techniques like NMR spectroscopic analysis and crystallography. The process involves treating glycoprotein-secreting mammalian cells with low endomannosidase activity under specific cell culture conditions using a glucosidase I inhibitor. After purification, the active glycoprotein undergoes treatment with endoglycosidase H to yield a glycoprotein with a single GlcNAc residue at each glycosylation sequon.
Career Highlights: Simon J Davis is associated with Monsanto Company, where he has collaborated on various innovative biotechnology projects. His contributions are paramount in advancing methodologies for studying glycoproteins, thus paving the way for better understanding and potential therapeutic applications.
Collaborations: Throughout his career, Simon has worked alongside esteemed colleagues, including Terence D Butters and Gunilla B Karlsson. This collaborative effort has fostered a dynamic research environment, facilitating the development of groundbreaking solutions in glycoprotein engineering.
Conclusion: Simon J Davis exemplifies the innovation present in the field of biotechnology through his patent on carbohydrate engineering of glycoproteins. His role at Monsanto Company and collaboration with other experts underscore the significance of teamwork in achieving remarkable advancements in scientific research. Simon's work continues to inspire future inventions that have the potential to transform the landscape of biochemical research.