This inventor holds 7 USPTO granted patents. Top assignees: Yale University, Other. Active years: 1985-2017. Nobel Prize laureate.
Location History:
- Hamden, MA (US) (1992)
- Hamden, CT (US) (1985 - 2017)
Company Filing History:
6 out of 1,363 
1 out of 834,411 Years Active: 1985-2017
Title: **Innovative Contributions of Sidney Altman in Antimicrobial Research**
Introduction
Sidney Altman, an eminent inventor based in Hamden, CT (US), has made significant strides in the field of antimicrobial research. With a total of 7 patents to his name, Altman's inventions focus on innovative methodologies to combat drug-resistant bacteria. His work has immense implications for treating infections that are resistant to traditional antimicrobial drugs.
Latest Patents
Among Sidney Altman's notable patents are two significant inventions aimed at enhancing antimicrobial efficacy:
1. **Antimicrobial compositions and methods of use thereof** - This patent discloses antimicrobial compositions comprising a cell-penetrating peptide (CPP) that possesses intrinsic antimicrobial properties. The CPP facilitates the improved delivery and effectiveness of a functional nucleic acid, specifically an external guide sequence (EGS), which targets microbial genes associated with resistance to antimicrobial agents. The methods outlined involve using these compositions alone or in conjunction with existing antimicrobial drugs to treat various infections effectively.
2. **Phenotypic conversion of drug-resistant bacteria to drug-sensitivity** - This innovation leverages external guide sequences (EGS) to achieve RNAase P-mediated cleavage of RNA that allows bacterial cells to regain sensitivity to antibiotics. By administering a vector encoding EGS to individuals with antibiotic-resistant bacteria, Altman's method aims to alter the genetic makeup of these bacteria, making them susceptible to antibiotic therapy. The approach promises a rapid spread of plasmids within resistant bacterial populations, enhancing the treatability of these infections.
Career Highlights
Sidney Altman's illustrious career includes tenure at respected institutions like Yale University, where his research and innovations have received significant recognition. His work is not only groundbreaking but also essential in addressing the urgent clinical challenges posed by antibiotic resistance.
Collaborations
Throughout his career, Sidney Altman has collaborated with distinguished colleagues, including Cecilia L Guerrier-Takada and Yan Yuan. These collaborations have contributed to enriching his research and expanding the application of his discoveries in real-world scenarios.
Conclusion
Sidney Altman's innovative contributions to antimicrobial research exemplify the critical role of inventors in addressing global health challenges. His patents demonstrate remarkable potential to revolutionize the treatment of drug-resistant infections and underscore the importance of continued research and collaboration in the field. With his ongoing efforts, Altman remains a key figure in the pursuit of effective antimicrobial solutions.