ShiXian Lin

Title: Innovations of ShiXian Lin in Bioconjugation

Introduction

ShiXian Lin is an accomplished inventor based in Berkeley, CA. He has made significant contributions to the field of bioconjugation, particularly through his innovative patent related to redox-based reagents. His work focuses on enhancing the chemoselective conjugation processes, which are crucial for various applications in biochemistry and molecular biology.

Latest Patents

ShiXian Lin holds a patent titled "Redox-based reagents for methionine bioconjugation." This patent describes a method for achieving chemoselective conjugation through redox reactivity. The process involves reacting an N-transfer oxidant with a thioether substrate in an aqueous environment to form a conjugation product. The patent also introduces Redox-Activated Chemical Tagging (ReACT) strategies for methionine-based protein functionalization. In this context, Oxaziridine (Ox) compounds are utilized as oxidant-mediated reagents, converting methionine to the corresponding sulfimide conjugation product. This innovative approach has the potential to advance the field of protein engineering.

Career Highlights

ShiXian Lin is affiliated with the University of California, where he continues to conduct research and develop new methodologies in bioconjugation. His work has garnered attention for its practical applications in protein functionalization, which is essential for various scientific and medical advancements.

Collaborations

ShiXian Lin collaborates with notable colleagues, including XiaoYu Yang and F Dean Toste. These partnerships enhance the research environment and contribute to the development of innovative solutions in the field.

Conclusion

ShiXian Lin's contributions to the field of bioconjugation through his patent on redox-based reagents exemplify the importance of innovation in scientific research. His work not only advances our understanding of protein functionalization but also opens new avenues for future research and applications.