Company Filing History:
Years Active: 2021
Title: Shilei Zhu: Innovator in Glycoprotein Engineering
Introduction
Shilei Zhu is a prominent inventor based in Halethorpe, MD (US). He has made significant contributions to the field of glycoprotein engineering, particularly through his innovative work on fucosidase mutants.
Latest Patents
Shilei Zhu holds a patent titled "Designer α 6-fucosidase mutants enable direct core fucosylation of intact N-glycopeptides and N-glycoproteins." This invention provides novel fucosidase mutants that serve as fuco-ligases for core fucosylation of various biological glycopeptides and glycoproteins, including intact therapeutic antibodies. Several mutants, such as E274A, E274S, and E274G, have been shown to efficiently fucosylate a wide variety of complex N-glycopeptides and intact glycoproteins. These site-specific mutants facilitate the transfer of fucose to a core GlcNAc-Asn residue, making them useful for drug delivery and vaccine development.
Career Highlights
Shilei Zhu is affiliated with the University System of Maryland, where he continues to advance research in glycoprotein technology. His work has garnered attention for its potential applications in therapeutic development.
Collaborations
Shilei Zhu has collaborated with notable colleagues, including Lai-Xi Wang and Chao Li, to further enhance the impact of his research in the field.
Conclusion
Shilei Zhu's innovative work in glycoprotein engineering exemplifies the importance of scientific research in developing new therapeutic solutions. His contributions through patents and collaborations highlight his role as a key inventor in this vital area of study.