Shih-Chia Tso

Title: Innovations by Shih-Chia Tso in Mitochondrial Pyruvate Dehydrogenase Kinase Inhibitors

Introduction

Shih-Chia Tso is an accomplished inventor based in Carrollton, TX (US). She has made significant contributions to the field of biochemistry, particularly in the development of inhibitors for mitochondrial pyruvate dehydrogenase kinase (PDK) isoforms. Her work has implications for treating various diseases, including diabetes, cardiovascular disease, and cancer.

Latest Patents

Shih-Chia Tso holds a patent titled "Inhibitors of mitochondrial pyruvate dehydrogenase kinase isoforms 1-4 and uses thereof." This patent focuses on the identification of PDK inhibitors and their therapeutic applications. The invention aims to develop robust PDK inhibitors that enhance glucose metabolism and correct metabolic dysfunction in vivo. By making a single functional-group change in a known Hsp90 inhibitor, Tso's approach efficiently converted it into a highly specific inhibitor for all PDK isoforms. These inhibitors significantly augment PDC activity while reducing phosphorylation in tissues.

Career Highlights

Shih-Chia Tso is affiliated with the University of Texas System, where she continues her research and innovation in biochemistry. Her work has garnered attention for its potential to address critical health issues through metabolic regulation.

Collaborations

Some of her notable coworkers include David T Chuang and Xiangbing Qi, who have collaborated with her on various research projects.

Conclusion

Shih-Chia Tso's innovative work in developing PDK inhibitors represents a significant advancement in the treatment of metabolic diseases. Her contributions to science and medicine continue to pave the way for future research and therapeutic strategies.