Shi-Shan Mao

Title: Shi-Shan Mao: Innovator in HCV Protease Research

Introduction

Shi-Shan Mao is a notable inventor based in North Wales, PA (US). He has made significant contributions to the field of biochemistry, particularly in the development of innovative substrates for HCV protease. With a total of 2 patents, his work has implications for both research and clinical applications.

Latest Patents

Mao's latest patents include a novel HCV protease substrate that features a europium label and a quenching group. This substrate is designed to be used in a time-resolved fluorescence (TRF) assay, which measures HCV protease activity. Another important patent is a process for producing activated thrombin-activatable fibrinolysis inhibitor (TAFIa). This invention outlines a method for purifying TAFIa from serum samples while in the presence of a reversible inhibitor, as well as a method for measuring TAFIa activity.

Career Highlights

Throughout his career, Shi-Shan Mao has worked with prominent companies such as Merck Sharp & Dohme Corp. and Merck & Co., Inc. His experience in these organizations has allowed him to contribute to significant advancements in pharmaceutical research and development.

Collaborations

Mao has collaborated with esteemed colleagues, including S Dale Lewis and Dennis Colussi. These partnerships have fostered an environment of innovation and have led to the successful development of his patented technologies.

Conclusion

Shi-Shan Mao's contributions to the field of biochemistry, particularly in HCV protease research, highlight his role as an influential inventor. His patents and collaborations reflect a commitment to advancing scientific knowledge and improving healthcare solutions.