Shi-Min Fang

Title: Innovations of Shi-Min Fang in Transcriptional Regulation

Introduction

Shi-Min Fang is a notable inventor based in San Diego, CA, who has made significant contributions to the field of molecular biology. He holds 2 patents that focus on the regulation of HIV transcriptional processes. His work has implications for understanding and potentially treating HIV infections.

Latest Patents

Fang's latest patents include a transcriptional coactivator that interacts with the Tat protein and regulates its binding to TAR RNA. This invention has led to the discovery of a host cell protein that is crucial for Tat transactivation. The protein, known as cyclin T1, is an 87 kDa cyclin partner for the PITALRE kinase. It has been found that Tat must interact with the TAK/TEFb complex to bind to TAR RNA with the necessary affinity and sequence specificity observed in vivo. Additionally, formulations useful for modulating Tat transactivation have been developed, along with assays for identifying compounds that can influence these processes.

Career Highlights

Shi-Min Fang is affiliated with the Salk Institute for Biological Studies, where he conducts his research. His work has been instrumental in advancing the understanding of HIV transcriptional regulation.

Collaborations

Fang has collaborated with notable colleagues, including Katherine A Jones and Ping Wei, who have contributed to his research endeavors.

Conclusion

Shi-Min Fang's innovative work in transcriptional regulation highlights the importance of understanding molecular interactions in the context of HIV. His patents pave the way for future research and potential therapeutic developments.