Sheryl T Smith

Title: Sheryl T Smith: Innovator in Mammalian Recombinase Genes

Introduction

Sheryl T Smith is a notable inventor based in Bryn Mar, Pennsylvania. She has made significant contributions to the field of genetics, particularly in the area of mammalian recombinase genes.

Latest Patents

Sheryl holds a patent for her invention titled "Mammalian and human REC2." This invention concerns mammalian recombinase genes (REC2) and their promoters. The overexpression of REC2 in a cell has been found to facilitate homologous recombination, especially when using a DNA/RNA chimeric oligonucleotide. Additionally, it sensitizes a cell to the apoptotic effects of irradiation. The REC2 promoter, when combined with a strong enhancer, such as an SV40 enhancer, has proven to be a robust promoter following cell irradiation. This radiation-inducible promoter can be utilized to sensitize a cell to radiation treatment by operably linking it to a gene that converts a prodrug to a drug, such as the herpes thymidine kinase gene.

Career Highlights

Throughout her career, Sheryl has focused on advancing the understanding of genetic mechanisms and their applications in medical treatments. Her work has implications for improving therapeutic strategies in cancer treatment and other diseases.

Collaborations

Sheryl has collaborated with esteemed colleagues, including Eric B Kmiec and William K Holloman, contributing to a rich exchange of ideas and research advancements in her field.

Conclusion

Sheryl T Smith's innovative work in mammalian recombinase genes highlights her significant role in genetic research and its potential applications in medicine. Her contributions continue to pave the way for advancements in therapeutic strategies.