Sher Bahadur Karki

Title: Innovator Profile: Sher Bahadur Karki

Introduction:

Sher Bahadur Karki, based in Pomona, California, is a prominent inventor known for his significant contributions to the field of biopharmaceuticals. With an impressive portfolio of 68 patents, Karki has made notable advancements in immunoglobulin engineering and therapeutic applications.

Latest Patents:

Among Karki's latest innovations are two notable patents concerning Fc variants with altered binding to FcRn. The first patent application, "Fc variants with altered binding to FcRn," focuses on optimized IgG immunoglobulin variants, detailing engineering methods for their generation and therapeutic applications. The second patent builds on this concept by describing a variant Fc region that includes specific modifications to the wild-type human Fc region, enhancing its functionality. The modifications highlighted in this application include 434S, 252Y/428L, 252Y/434S, and 428L/434S, with the modification numbering aligning with the EU index.

Career Highlights:

Sher Bahadur Karki currently works at Xencor, Inc., a company renowned for its innovative approach to antibody engineering and development. His role at Xencor has positioned him at the forefront of biopharmaceutical research, contributing to the advancement of therapies that are both effective and safe. His extensive patent portfolio reflects his expertise and commitment to the field.

Collaborations:

Throughout his career, Karki has collaborated with distinguished colleagues such as Gregory Alan Lazar and John R Desjarlais. These collaborations have facilitated the sharing of knowledge and resources, further driving innovations in the development of therapeutic molecules.

Conclusion:

Sher Bahadur Karki's contributions to the field of biotechnology cannot be understated. With his substantial number of patents and collaborative efforts, he continues to inspire future innovations in immunoglobulin therapies. His work at Xencor, Inc. shows a dedication to advancing healthcare through scientific discoveries and applications.