Shengjie Guo

Title: Innovations of Shengjie Guo in DNA Recognition

Introduction

Shengjie Guo is a prominent inventor based in Beijing, China. He has made significant contributions to the field of molecular biology, particularly in the area of DNA recognition and modification. His work focuses on developing innovative tools for gene editing and detection.

Latest Patents

Shengjie Guo holds a patent titled "Tale RVD specifically recognizing DNA base modified by methylation and application thereof." This invention identifies RVDs with recognition preferences for 5mC, 5hmC, and 6 mA, showcasing different binding properties to these epigenetic modifications. The patent outlines methods for methylation-dependent gene activation, efficient genome editing, and targeted detection of 5hmC. It provides an isolated DNA binding polypeptide containing TALEs, a fusion protein, a polynucleotide, a vector comprising the polynucleotide, and a host cell. The invention also details the use of the protein comprising TALE repeats domain in preparing a reagent for detecting a methylated base in a target sequence of a gene of interest.

Career Highlights

Throughout his career, Shengjie Guo has worked with esteemed institutions such as Peking University and Edigene Inc. His research has significantly advanced the understanding of DNA modifications and their implications in gene regulation.

Collaborations

Shengjie Guo has collaborated with notable colleagues, including Wensheng Wei and Chengqi Yi. Their joint efforts have contributed to the development of innovative solutions in the field of genetic research.

Conclusion

Shengjie Guo's work in DNA recognition and modification represents a significant advancement in molecular biology. His innovative patents and collaborations highlight his commitment to enhancing gene editing technologies and their applications.