Sheng Hu

Title: Innovations of Sheng Hu in Enzyme Engineering

Introduction

Sheng Hu is a notable inventor based in Hangzhou, China. He has made significant contributions to the field of enzyme engineering, particularly through his innovative work on ω-transaminase mutants. His research focuses on enhancing the efficiency and stability of enzymes, which has important implications for various industrial applications.

Latest Patents

Sheng Hu holds a patent for a novel ω-transaminase mutant obtained by DNA synthetic shuffling combined mutation. The invention discloses a method for creating a mutant enzyme through point mutation of a wild type ω-transaminase. The amino acid sequence of the wild type ω-transaminase is detailed in SEQ ID NO: 1. The mutation sites of the ω-transaminase mutant include several combinations, such as F115L-H210N-M150C-M280C and I77L-Q97E-F115L-L118T-E253A-G292D. This innovative approach has been verified through experiments to improve the probability of forward mutation and enhance the thermodynamic stability of the enzymes compared to their wild counterparts.

Career Highlights

Sheng Hu has worked with prominent organizations, including Enzymaster Bio-Engineering Co., Ltd. and Zhejiang University. His experience in these institutions has allowed him to collaborate with other experts in the field and contribute to groundbreaking research in enzyme technology.

Collaborations

Some of his notable coworkers include Chunyan Liu and Weirui Zhao. Their collaborative efforts have further advanced the research and development of enzyme engineering.

Conclusion

Sheng Hu's innovative work in the field of enzyme engineering, particularly through his patented ω-transaminase mutant, showcases his significant contributions to science and industry. His research not only enhances enzyme stability but also improves experimental efficiency, paving the way for future advancements in biotechnology.