This inventor holds 1 USPTO granted patent. Top assignees: Massachusetts Institute of Technology, New England Medical Center Hospitals. Inc., Tufts University. Active years: 1999.
Company Filing History:
1 out of 8,578 
1 out of 97 
1 out of 655 
Years Active: 1999
Title: Sheldon M. Wolff: A Pioneer in Biologically Active Fragments of IL-1
Introduction
Sheldon M. Wolff was a notable inventor whose contributions to the field of immunology have left a lasting impact. He was particularly recognized for his work on biologically active fragments of interleukin-1 (IL-1). His innovative research has paved the way for advancements in understanding immune responses.
Latest Patents
Wolff held a patent for a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1) and its fragments. This invention involved the cloning of a cDNA synthesized by reverse transcription of poly(A)RNA isolated from adherent human monocytes stimulated with bacterial endotoxin. The human IL-1 is crucial for inducing the production of IL-2 by activated T-cells and also acts on B-cells and NK-cells. Additionally, the patent concerns antibodies that are immunoreactive with human IL-1β proteins. He was credited with 1 patent.
Career Highlights
Throughout his career, Wolff worked with prestigious institutions, including New England Medical Center Hospitals, Inc. and the Massachusetts Institute of Technology. His research and findings have significantly contributed to the understanding of immune system functions.
Collaborations
Wolff collaborated with esteemed colleagues such as Philip E. Auron and Charles A. Dinarello. Their collective efforts have further advanced the field of immunology and the study of interleukins.
Conclusion
Sheldon M. Wolff's innovative work in the field of immunology, particularly regarding interleukin-1, has made a significant impact on medical research. His legacy continues to influence the scientific community today.