Company Filing History:
Years Active: 2005
Title: Sheila Macintyre-Ayane: Innovator in Microbial Protein Expression Systems
Introduction
Sheila Macintyre-Ayane is a prominent inventor based in Reading, GB. She has made significant contributions to the field of biotechnology, particularly in the development of microbial protein expression systems. Her innovative work has led to the creation of a patented technology that enhances the production of biologically active recombinant proteins.
Latest Patents
Sheila holds a patent for a microbial protein expression system. This invention provides bacterial strains that facilitate the secretion of soluble biologically active recombinant heterologous proteins into the periplasm or onto the surface of bacteria. The technology exploits the secretion system of Gram-negative bacteria, utilizing periplasmic chaperones and usher/secretin proteins. The bacterial strains express a fusion protein that includes a signal peptide, a mature heterologous protein, and a subunit of a bacterial surface structure, Caf1. This innovative approach allows for the efficient secretion of various fusion proteins, including human IL-1β, GM-CSF, and IL-1ra.
Career Highlights
Sheila Macintyre-Ayane is associated with Biotecnol S.A., where she continues to advance her research and development efforts. Her work has garnered attention for its potential applications in therapeutic protein production and other biotechnological fields. With her expertise, she has contributed to the understanding of protein secretion mechanisms in bacteria.
Collaborations
Sheila collaborates with notable colleagues, including Timo Korpela and Anton Zavialov. Their combined efforts in research and development have furthered the advancements in microbial protein expression technologies.
Conclusion
Sheila Macintyre-Ayane's innovative contributions to microbial protein expression systems highlight her role as a leading inventor in biotechnology. Her patented technology has the potential to revolutionize the production of recombinant proteins, paving the way for future advancements in the field.