Shawn Gallagher

Title: Innovations by Shawn Gallagher in Adenoviral Vector Production

Introduction

Shawn Gallagher is an accomplished inventor based in Missouri City, TX (US). He has made significant contributions to the field of biotechnology, particularly in the production and purification of adenoviral vectors. With a total of 2 patents to his name, Gallagher's work addresses critical challenges in viral vector production.

Latest Patents

Gallagher's latest patents focus on methods for improving the yields of adenoviral vectors when grown in cell culture systems. His inventions demonstrate that utilizing low-medium perfusion rates in an attached cell culture system can enhance yields. Additionally, he has shown that improved Ad-p53 production can be achieved with cells grown in serum-free conditions, particularly in serum-free suspension culture. The use of detergent lysis is also crucial for increasing yields. By combining these innovative aspects, Gallagher's methods allow for the purification of viruses through a single chromatography step, resulting in purified virus of comparable quality to those prepared using double CsCl banding with an ultracentrifuge.

Career Highlights

Throughout his career, Shawn Gallagher has worked with notable companies in the biotechnology sector, including Introgen Therapeutics Inc. and Crucell Holland B.V. His experience in these organizations has contributed to his expertise in viral vector production and purification.

Collaborations

Gallagher has collaborated with talented individuals in his field, including Shuyuan Zhang and Capucine Thwin. These partnerships have likely enhanced the development and implementation of his innovative methods.

Conclusion

Shawn Gallagher's contributions to the field of adenoviral vector production are noteworthy. His innovative methods have the potential to significantly improve the efficiency and quality of viral vector production, making a lasting impact in biotechnology.