Shashikanth Ponnala

Title: Shashikanth Ponnala: Innovator in Therapeutic Imaging

Introduction

Shashikanth Ponnala is a notable inventor based in Secaucus, NJ (US). He has made significant contributions to the field of therapeutic imaging, particularly in the development of novel chelators for radiolabels. His work aims to enhance the safety and efficacy of PET imaging techniques.

Latest Patents

Ponnala holds a patent for "Compositions for therapeutics, targeted PET imaging and methods of their use." This patent describes a chelator for radiolabels, such as Zirconium (Zr), which serves as an alternative to DFO. The ligand, 3,4,3-(LI-1,2-HOPO) ('HOPO'), demonstrates equal or superior stability compared to DFO in various chemical and biological assays over several days in vivo. The HOPO is an octadentate chelator that effectively stabilizes the chelation of radiolabels. Additionally, a bifunctional ligand comprising p-SCN-Bn-HOPO is designed to minimize the loss of Zr from the chelate in vivo, thereby reducing uptake in bone and non-target tissues. This innovation facilitates safer and improved PET imaging with radiolabeled antibodies.

Career Highlights

Throughout his career, Ponnala has worked with prestigious institutions, including Memorial Sloan Kettering Cancer Center and City University of New York. His experience in these organizations has allowed him to collaborate with leading experts in the field of medical imaging and therapeutics.

Collaborations

Some of his notable coworkers include Jason S. Lewis and Melissa Deri. Their collaborative efforts have contributed to advancements in therapeutic imaging and the development of innovative solutions in the medical field.

Conclusion

Shashikanth Ponnala's contributions to the field of therapeutic imaging through his innovative patent work highlight his role as a significant inventor. His advancements in chelator technology are poised to improve the safety and effectiveness of PET imaging techniques.