The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2020
Filed:
Sep. 09, 2016
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Research Foundation of the City University of New York, New York, NY (US);
Jason S. Lewis, New York, NY (US);
Melissa Deri, Hottsville, NY (US);
Lynn Francesconi, Bridgewater, NJ (US);
Shashikanth Ponnala, Secaucus, NJ (US);
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Research Foundation of the City University of New York, New York, NY (US);
Abstract
Described herein is a chelator for radiolabels (e.g.,Zr) for targeted PET imaging that is an alternative to DFO. In certain embodiments, the chelator forZr is the ligand, 3,4,3-(LI-1,2-HOPO) ('HOPO'), which exhibits equal or superior stability compared to DFO in chemical and biological assays across a period of several days in vivo. As shown in FIG., the HOPO is an octadentate chelator that stabilizes chelation of radiolabels (e.g.,Zr). A bifunctional ligand comprising p-SCN-Bn-HOPO is shown in FIG.and FIG.. Such a bifunctional ligand can eliminate (e.g.,Zr) loss from the chelate in vivo and reduce uptake in bone and non-target tissue. Therefore, the bifunctional HOPO ligand can facilitate safer and improved PET imaging with radiolabeled antibodies.