Location History:
- Seaucus, NJ (US) (2010)
- Secaucus, NJ (US) (2012)
Company Filing History:
Years Active: 2010-2012
Title: Sharmistha Das: Innovator in Breast Cancer Therapeutics
Introduction
Sharmistha Das is a prominent inventor based in Secaucus, NJ (US). She has made significant contributions to the field of cancer research, particularly in developing innovative methods for treating breast cancer. With a total of 2 patents, her work focuses on utilizing NRIF3 related molecules to induce apoptosis in breast cancer cells.
Latest Patents
Sharmistha Das's latest patents revolve around the discovery that the NRIF3 family of transcriptional coregulators can induce rapid and profound apoptosis in breast cancer cells. This process results in nearly 100% cell death within 24 hours. A novel death domain (DD1) was identified, which is mapped to a short 30 amino acid region common to all members of the NRIF3 family. Additionally, two other death domains (DD2 and DD3) were found to exhibit effective breast cancer killing activities. Mechanistic studies revealed that DD1-induced apoptosis occurs through a novel caspase-2 mediated pathway, involving mitochondrial membrane permeabilization without the need for other caspases. Notably, the cytotoxicity of NRIF3 related molecules is cell-type specific, selectively targeting breast cancer cells while sparing other cell types. This suggests the presence of a specific death switch in breast cancer cells that can be triggered by NRIF3 and related molecules. Furthermore, strategies for utilizing NRIF3 related molecules and targeting this death switch are disclosed for developing novel and more selective therapeutics against breast cancer.
Career Highlights
Sharmistha Das is affiliated with New York University, where she continues her research and innovation in cancer therapeutics. Her work has garnered attention for its potential to revolutionize treatment options for breast cancer patients.
Collaborations
Some of her notable coworkers include Li Dangsheng and Herbert H Samuels, who contribute to her research endeavors.
Conclusion
Sharmistha Das is a trailblazer in the field of breast cancer research, with her innovative methods showing promise for more effective treatments. Her contributions are paving the way for advancements in cancer therapeutics.