Shang-Chia Chang

Title: Innovations of Shang-Chia Chang in Nucleic Acid Sequencing

Introduction

Shang-Chia Chang is a prominent inventor based in Zhubei, Taiwan. He has made significant contributions to the field of nucleic acid sequencing, holding a total of five patents. His work focuses on enhancing the accuracy and efficiency of sequencing methods, which are crucial for various applications in genomics and biotechnology.

Latest Patents

Chang's latest patents include innovative methods and compositions for sequencing nucleic acids. One notable patent describes methods that utilize nucleotide analogs and a nucleic acid polymerase enzyme or enzyme complex with proofreading activity. This approach allows for the incorporation of nucleotide analogs into a replicating strand, which enhances the proofreading activity of the polymerizing enzyme. As a result, this prolongs the duration of the signal associated with nucleotide incorporation, leading to more observable sequencing events and improved accuracy in nucleic acid sequencing. Another significant invention involves nucleotide analogs for a real-time sequencing method for single molecules. This method employs an enzyme or enzyme complex with multiple enzymatic activities and a set of nucleotide analogs to achieve high signal readout accuracy. The long signaling time span of each signal allows for greater clarity in the sequencing process.

Career Highlights

Throughout his career, Shang-Chia Chang has worked with notable organizations such as the Industrial Technology Research Institute and Personal Genomics, Inc. His experience in these institutions has contributed to his expertise in the field of genetic research and sequencing technologies.

Collaborations

Chang has collaborated with esteemed colleagues, including Tsu-Ju Fu and Jenn-Yeh Fann. These partnerships have facilitated advancements in his research and innovations in nucleic acid sequencing.

Conclusion

Shang-Chia Chang's contributions to nucleic acid sequencing through his patents and collaborations highlight his role as a key innovator in the field. His work continues to influence advancements in genetic research and biotechnology.