Company Filing History:
2 out of 495 
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1 out of 213 
Years Active: 2021-2025
Title: Innovations of Shane Miersch
Introduction
Shane Miersch is a notable inventor based in Toronto, Canada. He has made significant contributions to the field of biotechnology, particularly in the development of human antibodies and agents targeting the Epidermal Growth Factor Receptor (EGFR). His work has implications for treating various diseases, including cancer and autoimmune disorders.
Latest Patents
Shane Miersch holds two patents that showcase his innovative approach to medical treatments. The first patent involves human antibodies to the human interleukin 18 receptor alpha or beta. This patent provides antibodies or fragments that specifically bind to the anti-IL-18 receptor alpha or beta. It also outlines methods for using these antibodies in the treatment and diagnosis of diseases such as cancer and inflammatory conditions. The second patent focuses on EGFR-binding agents. This invention describes an EGFR-binding agent that includes a heavy chain and a light chain, with a dimerization loop from EGFR's Domain II grafted within the complementarity determining region 3 (CDR3) of the heavy chain. This design allows the binding agent to inhibit EGFR dimerization and activation, which is crucial for targeting EGFR-expressing cells.
Career Highlights
Shane Miersch has worked at prestigious institutions, including the University of Toronto and ShanghaiTech University. His experience in these research environments has allowed him to collaborate with leading scientists and contribute to groundbreaking research in his field.
Collaborations
Shane has collaborated with notable colleagues, including Sachedv S Sidhu and Donghui Wu. These partnerships have enhanced his research and innovation efforts, leading to significant advancements in biotechnology.
Conclusion
Shane Miersch's contributions to the field of biotechnology through his patents and collaborations highlight his role as an influential inventor. His work continues to pave the way for new treatments and diagnostic methods in medicine.