Shadi Toghi Eshghi

Title: Shadi Toghi Eshghi: Innovator in Mass Spectrometry

Introduction

Shadi Toghi Eshghi is a prominent inventor based in Baltimore, MD (US). He has made significant contributions to the field of mass spectrometry, particularly in the analysis of glycans from biological samples. With a total of 2 patents, his work has advanced the methodologies used in this critical area of research.

Latest Patents

Eshghi's latest patents focus on mass spectrometry imaging of glycans from tissue sections and improved analyte detection methods. The disclosed methods utilize mass spectrometry for direct profiling of N-linked glycans from biological samples. Additionally, he has introduced novel methods known as targeted analyte detection (TAD) to enhance the detection limit of MALDI-MS. These methods leverage the carrier effect of added standard analytes, which is influenced by the sigmoidal shape of the calibration curve. The functionality of TAD is based on the relative enhancement of sensitivity compared to the increase in standard deviation during the analysis of target analytes with spiking in exogenous concentration. At specific ranges of exogenous concentration, the increase in sensitivity surpasses the standard deviation, leading to an improved limit of detection (LOD). Theoretically, exogenous concentrations around 1 LODorig yield optimal LOD improvement. TAD is a cost-effective method that is versatile and can be applied to enhance the detection of various analytes using different detection methods, provided that the analyte can be extracted or is available in synthetic form.

Career Highlights

Shadi Toghi Eshghi is affiliated with Johns Hopkins University, where he continues to push the boundaries of research in mass spectrometry. His innovative approaches have garnered attention in the scientific community, contributing to advancements in analytical techniques.

Collaborations

Eshghi has collaborated with notable colleagues, including Xingde Li and Hui Zhang, further enriching his research endeavors and expanding the impact of his work.

Conclusion

Shadi Toghi Eshghi is a key figure in the field of mass spectrometry, with a focus on glycans and analyte detection methods. His contributions are paving the way for future innovations in this vital area of research.