Seshu Tummala

Title: Innovations by Seshu Tummala

Introduction

Seshu Tummala is an accomplished inventor based in Newburyport, MA (US). He has made significant contributions to the field of bioprocessing through his innovative patents. With a total of 2 patents, Tummala's work focuses on enhancing the monitoring and control of cell culture processes.

Latest Patents

One of Tummala's latest patents is titled "Automated control of cell culture using Raman spectroscopy." This invention provides a method for monitoring and controlling bioprocesses by generating generic calibration models that are independent of cell lines. The use of inline Raman probes allows for the monitoring of critical parameters such as glucose, lactate, glutamate, ammonium, viable cell concentration (VCC), total cell concentration (TCC), and product concentration. The calibration models were developed using two different CHOK1SV GS-KO™ cell lines that produce different monoclonal antibodies (mAbs). The predictive models created were validated using an independent CHOK1SV GS-KO™ cell line, demonstrating minor prediction errors throughout the cell culture process. This innovation enables the application of spectroscopic Process Analytical Technology (PAT) techniques in clinical manufacturing environments, where processes are typically executed based on a common platform.

Career Highlights

Tummala is currently employed at Lonza Inc., a leading company in the life sciences sector. His work at Lonza has allowed him to contribute to advancements in bioprocessing technologies.

Collaborations

Throughout his career, Tummala has collaborated with notable colleagues, including Thaddaeus Webster and Brian Hadley. These collaborations have further enriched his research and development efforts.

Conclusion

Seshu Tummala's innovative work in bioprocessing, particularly through his patents, showcases his commitment to advancing the field. His contributions are paving the way for more efficient and effective biomanufacturing processes.