Sergey Borisov

Title: Innovations of Sergey Borisov in Oxygen Monitoring

Introduction

Sergey Borisov is a notable inventor based in Graz, Austria. He has made significant contributions to the field of biomedical research, particularly in the area of oxygen monitoring in live mammalian cells. With a total of 2 patents, his work has the potential to advance our understanding of cellular metabolism and oxygen dynamics.

Latest Patents

One of his latest patents is a method and probe for monitoring oxygen status in live mammalian cells. This innovative method determines oxygen concentration, metabolic activity, and the effects of test substances on the metabolic activity of live cell samples using a photoluminescence quenching technique. The photoluminescent probe is designed to self-load into the cells without the need for loading reagents. It consists of polymeric particles that feature an amphiphilic cationic polymer matrix with a hydrophobic core and a hydrophilic positively charged surface. The probe also includes a hydrophobic oxygen-sensitive photoluminescent dye embedded in the core, allowing for effective intracellular sensing of oxygen levels.

Another patent by Borisov focuses on the use of photoluminescent probes for intracellular oxygen sensing. This invention utilizes a suspension of polymeric particles with an average diameter ranging from 20 nm to 100 nm. The particles are formed from an amphiphilic cationic co-polymer, which provides a hydrophobic core and a hydrophilic shell. The probe incorporates a hydrophobic oxygen-sensitive photoluminescent dye, such as Pt-tetrakis(pentafluorophenyl)porphine, embedded in the hydrophobic core. This innovative approach allows for the detection of photoluminescent signals that correlate with oxygen status in live mammalian cells.

Career Highlights

Sergey Borisov is affiliated with University College Cork, where he continues to contribute to research and innovation in the field of biomedicine. His work has garnered attention for its potential applications in understanding cellular responses to oxygen levels and metabolic changes.

Collaborations

Borisov has collaborated with notable researchers, including Dmitri Boris Papkovsky and Andreas Fercher. These collaborations have further enriched his research and expanded the impact of his inventions in the scientific community.

Conclusion

Sergey Borisov's innovative work in the field of oxygen monitoring represents a significant advancement in biomedical