Location History:
- Mishawaka, IN (US) (2018)
- South Bend, IN (US) (2022)
Company Filing History:
Years Active: 2018-2022
Title: Innovations in Antibacterial Agents by Serena Carosso
Introduction
Serena Carosso is an accomplished inventor based in South Bend, IN (US). She has made significant contributions to the field of antibacterial agents, holding 2 patents that showcase her innovative research and development efforts. Her work focuses on the synthesis of novel compounds that enhance antibiotic activity against various bacterial strains.
Latest Patents
Carosso's latest patents include groundbreaking research on antibacterial monobactams. One of her notable inventions involves bromine-induced lactamization of vinyl acetohydroxamates, which facilitates the synthesis of monocyclic β-lactams. These compounds are suitable for incorporating thiomethyl and extended functionality at the C(4) position. The elaboration of the resulting substituted N-hydroxy-2-azetidinones allows for the incorporation of functionalized α-amino substituents, which are essential for enhancing antibiotic activity. Her evaluation of antibacterial activity against a panel of Gram-positive and Gram-negative bacteria has revealed important structure-activity relationships (SAR) and identified potent new monobactam antibiotics. Additionally, her research on peripherally substituted monocyclic beta-lactams provides valuable antibacterial agents or intermediates for the preparation of other useful compounds.
Career Highlights
Serena Carosso is affiliated with the University of Notre Dame Du Lac, where she continues her research and development in the field of antibacterial agents. Her work has garnered attention for its potential impact on addressing critical bacterial infections, particularly those strains listed by the WHO as being of critical concern worldwide.
Collaborations
Carosso collaborates with esteemed colleagues, including Marvin J. Miller and Rui Liu, to further advance her research initiatives. Their combined expertise contributes to the innovative solutions being developed in the realm of antibacterial agents.
Conclusion
Serena Carosso's contributions to the field of antibacterial agents through her innovative patents highlight her dedication to improving antibiotic efficacy. Her work not only addresses current challenges in bacterial resistance but also paves the way for future advancements in medical science.