Company Filing History:
Years Active: 2025
Title: Sebastian M Castillo-Hair: Innovator in Inducible Promoter Expression Systems
Introduction
Sebastian M Castillo-Hair is a prominent inventor based in Houston, TX. He has made significant contributions to the field of biotechnology, particularly in the development of expression systems. His innovative work has led to the creation of a unique inducible promoter expression system that has potential applications in various research areas.
Latest Patents
Sebastian holds a patent for an inducible promoter expression system based on T7 RNA Polymerase (T7 RNAP), lactose repressor (Lad), and a chimeric T7lac promoter (PT7lac). This system can be integrated as a single copy into the genome. In the absence of IPTG, Lad strongly represses T7RNAP and PT7lac, resulting in undetectable expression of the superfolder green fluorescent protein (sfGFP) reporter protein by flow cytometry. The addition of IPTG de-represses PT7lac and induces T7RNAP expression, leading to very high levels of sfGFP.
Career Highlights
Sebastian is affiliated with William Marsh Rice University, where he continues to advance his research in biotechnology. His work has garnered attention for its innovative approach to gene expression regulation. He has successfully demonstrated the effectiveness of his inducible promoter system in various experimental settings.
Collaborations
Sebastian collaborates with Jeffrey J Tabor, a fellow researcher at William Marsh Rice University. Their partnership has fostered advancements in the understanding and application of inducible expression systems.
Conclusion
Sebastian M Castillo-Hair is a notable inventor whose work in inducible promoter expression systems is paving the way for new advancements in biotechnology. His contributions are significant and continue to influence the field positively.