Location History:
- Tempe, AR (US) (2006)
- Tempe, AZ (US) (2003 - 2011)
Company Filing History:
3 out of 5 
3 out of 11 Years Active: 2003-2011
Title: Scott R Lefler: Innovator in Anticancer Research
Introduction
Scott R Lefler is a notable inventor based in Tempe, Arizona, recognized for his contributions to the field of anticancer research. He holds a total of six patents, showcasing his innovative approach to combating cancer through the regulation of protein prenylation.
Latest Patents
One of Scott R Lefler's latest patents focuses on anticancer agents based on the regulation of protein prenylation. Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when localized at the inner surface of a cancer cell membrane. This localization is facilitated by the prenylation reaction, where a hydrophobic group, such as a farnesyl group, is attached to the protein in the presence of an enzyme like farnesyl protein transferase. By deactivating the prenylation enzyme through covalent modification, it is possible to mitigate or even cease cancer cell growth. Various prenylation inhibitors with the necessary structural groups to bond covalently or irreversibly to the prenylation enzyme include carbonyl or thiocarbonyl compounds and alpha oxo-epoxides bonded to a hydrophobic, substrate-mimicking group. These compounds also contain a nucleofugal atom or group to enhance the tendency to form covalent bonds.
Career Highlights
Throughout his career, Scott R Lefler has worked with esteemed organizations such as the Arizona Disease Control Research Commission and the Arizona Biomedical Research Commission. His work in these institutions has significantly contributed to advancements in cancer research and treatment.
Collaborations
Scott has collaborated with notable individuals in his field, including Seth David Rose and Steven R Ottersberg. Their combined expertise has furthered the development of innovative solutions in cancer treatment.
Conclusion
Scott R Lefler's work in the field of anticancer research exemplifies the impact of innovation on healthcare. His patents and collaborations highlight the importance of scientific advancements in the fight against cancer.