Company Filing History:
Years Active: 1985-2004
Title: Scott M Bradley: Innovator in Oncogene Research
Introduction
Scott M Bradley is a prominent inventor based in McLean, VA (US). He has made significant contributions to the field of cancer research, particularly in the study of oncogenes. With a total of 4 patents, his work has advanced the understanding of genetic factors in cancer.
Latest Patents
Bradley's latest patents focus on oncogenes and methods for their detection. One of his notable inventions describes experiments designed to define the differences between the 21 oncogene of DNA isolated from human bladder cancer cells and its corresponding proto-oncogene. He also details the determination of differences between the rat neu oncogene and its corresponding proto-oncogene. His work includes the development of nucleic acid probes that are reactive with regions of the proto-oncogene or oncogene, along with methods for their use in detecting the occurrence of these genes. Additionally, he has described antibodies specific for gene products encoded by the neu genes and methods for their application.
Another significant patent involves antibodies specific for the ras proto-oncogene encoded P21 proteins. This research outlines experiments that define the differences between the p21 oncogene DNA isolated from human bladder cancer cells and its corresponding proto-oncogene. Through a series of in vitro recombinations, the difference was isolated to a 350 kb segment of DNA. Sequencing revealed a change in the Gly.sup.12 codon, resulting in the p21 protein of the oncogene containing valine, while the proto-oncogene contained glycine. His patents also describe assays for detecting carcinogenesis based on these genetic differences.
Career Highlights
Scott M Bradley is affiliated with the Massachusetts Institute of Technology, where he continues to contribute to groundbreaking research in oncology. His work has been instrumental in advancing the understanding of cancer at a molecular level.
Collaborations
Bradley has collaborated with notable scientists in the field, including Robert Allan Weinberg and Clifford J Tabin. These collaborations have further enriched his research and expanded the impact of his inventions.
Conclusion
Scott M Bradley's innovative work in oncogene research has led to significant advancements in cancer detection and understanding. His contributions continue to influence the field and pave the way for future discoveries.