Company Filing History:
Years Active: 2008-2009
Title: Scott Anthony Gerber: Innovator in Protein Quantification
Introduction
Scott Anthony Gerber is a prominent inventor based in Brookline, MA (US). He has made significant contributions to the field of protein quantification, holding 2 patents that enhance the understanding and analysis of proteins in complex biological mixtures.
Latest Patents
Gerber's latest patents include "Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry." This invention provides reagents, kits, and methods for detecting and quantifying proteins in complex mixtures, such as cell lysates. The methods can be utilized in high-throughput assays to profile cellular proteomes. One aspect of this invention features a peptide internal standard labeled with a stable isotope, corresponding in amino acid sequence to a subsequence of a target polypeptide. Another aspect involves a peptide internal standard labeled at a modified amino acid residue, which is used to determine the presence and quantify the amount of a particular modified form of a protein.
Another notable patent is "Capture and release based isotope tagged peptides and methods for using the same." This invention offers non-affinity based isotope tagged peptides, along with chemistries for their production and methods for their application. One aspect of the invention includes tags that comprise a reactive site for forming a stable association with a protein and an anchoring site group for reversibly or removably anchoring the tag to a solid phase, such as a resin support. The reagents developed can be employed for rapid and quantitative analysis of proteins or protein function in mixtures.
Career Highlights
Scott Anthony Gerber is affiliated with Harvard College, where he continues to advance research in protein analysis and mass spectrometry. His work has significantly impacted the scientific community, particularly in the realm of proteomics.
Collaborations
Gerber has collaborated with notable scientists, including Steven P. Gygi and Carlos Augusto Gartner, contributing to the advancement of research in his field.
Conclusion
Scott Anthony Gerber is a distinguished inventor whose work in protein quantification has led to innovative methods and technologies. His contributions continue to influence the field of proteomics and enhance our understanding of protein functions.