Company Filing History:
Years Active: 1998-2004
Title: Scott A Lesley: Innovator in Protein and Nucleic Acid Purification
Introduction
Scott A Lesley is a prominent inventor based in Oregon, WI (US), known for his significant contributions to the fields of protein and nucleic acid purification. With a total of 5 patents, Lesley has developed innovative methods that enhance the efficiency and effectiveness of various biochemical processes.
Latest Patents
Lesley's latest patents include groundbreaking work in the purification of proteins, peptides, and conjugates for immunization, purification, and detection applications. One notable patent describes a process for producing and purifying peptides and peptide/protein antigens for antibody production. This process utilizes fusion proteins, specifically those with a carrier segment that includes an amino acid sequence of at least about 65 amino acids long, devoid of negatively or positively charged side chains.
Another significant patent focuses on endotoxin reduction in nucleic acid purification. This invention presents a novel method for removing endotoxins from nucleic acids, such as DNA and RNA, which are often contaminated. The method employs silica-based materials, including silica gel particles and magnetic silica particles, to effectively isolate plasmid DNA from lysates of gram-negative bacteria. The application of this method results in nucleic acids that are sufficiently free of endotoxin contamination for various practical applications.
Career Highlights
Scott A Lesley has made substantial contributions to the scientific community through his innovative work at Promega Corporation. His expertise in protein and nucleic acid purification has positioned him as a key figure in the development of advanced biochemical techniques.
Collaborations
Lesley has collaborated with notable colleagues, including Mark W Knuth and Mary Haak-Frendscho, further enhancing the impact of his work in the field.
Conclusion
Scott A Lesley is a distinguished inventor whose innovative patents in protein and nucleic acid purification have made significant advancements in biotechnology. His contributions continue to influence the scientific community and improve various applications in the field.